• Genome-wide association analyses of physical activity and sedentary behavior provide insights into underlying mechanisms and roles in disease prevention 

      Wang, Zhe; Emmerich, Andrew; Pillon, Nicolas J.; Moore, Tim; Hemerich, Daiane; Cornelis, Marilyn C.; Mazzaferro, Eugenia; Broos, Siacia; Ahluwalia, Tarunveer S.; Bartz, Traci M.; Bentley, Amy R.; Bielak, Lawrence F.; Chong, Mike; Chu, Audrey Y.; Berry, Diane; Dorajoo, Rajkumar; Dueker, Nicole D.; Kasbohm, Elisa; Feenstra, Bjarke; Feitosa, Mary F.; Gieger, Christian; Graff, Mariaelisa; Hall, Leanne M.; Haller, Toomas; Hartwig, Fernando P.; Hillis, David A.; Huikari, Ville; Heard-Costa, Nancy; Holzapfel, Christina; Jackson, Anne U.; Johansson, Åsa; Jørgensen, Anja Moltke; Kaakinen, Marika A.; Karlsson, Robert; Kerr, Kathleen F.; Kim, Boram; Koolhaas, Chantal M.; Kutalik, Zoltan; Lagou, Vasiliki; Lind, Penelope A.; Lorentzon, Mattias; Lyytikäinen, Leo-Pekka; Mangino, Massimo; Metzendorf, Christoph; Monroe, Kristine R.; Pacolet, Alexander; Pérusse, Louis; Pool, Rene; Richmond, Rebecca C.; Rivera, Natalia V.; Robiou-du-Pont, Sebastien; Schraut, Katharina E.; Schulz, Christina-Alexandra; Stringham, Heather M.; Tanaka, Toshiko; Teumer, Alexander; Turman, Constance; van der Most, Peter J.; Vanmunster, Mathias; van Rooij, Frank J. A.; van Vliet-Ostaptchouk, Jana V.; Zhang, Xiaoshuai; Zhao, Jing-Hua; Zhao, Wei; Balkhiyarova, Zhanna; Balslev-Harder, Marie N.; Baumeister, Sebastian E.; Beilby, John; Blangero, John; Boomsma, Dorret I.; Brage, Søren Karl; Braund, Peter S.; Brody, Jennifer A.; Bruinenberg, Marcel; Ekelund, Ulf; Liu, Ching-Ti; Cole, John W.; Collins, Francis S.; Cupples, L. Adrienne; Esko, Tõnu; Enroth, Stefan; Faul, Jessica D.; Fernandez-Rhodes, Lindsay; Fohner, Alison E.; Franco, Oscar H.; Galesloot, Tessel E.; Gordon, Scott D.; Grarup, Niels; Hartman, Catharina A.; Heiss, Gerardo; Hui, Jennie; Illig, Thomas; Jago, Russell; James, Alan; Joshi, Peter K.; Jung, Taeyeong; Kähönen, Mika; Kilpeläinen, Tuomas O.; Koh, Woon-Puay; Kolcic, Ivana; Kraft, Peter P.; Kuusisto, Johanna; Launer, Lenore J.; Li, Aihua; Linneberg, Allan; Luan, Jian’an; Vidal, Pedro Marques; Medland, Sarah E.; Milaneschi, Yuri; Moscati, Arden; Musk, Bill; Nelson, Christopher P.; Nolte, Ilja M.; Pedersen, Nancy L.; Peters, Annette; Peyser, Patricia A.; Power, Christine; Raitakari, Olli T.; Reedik, Mägi; Reiner, Alex P.; Ridker, Paul M.; Rudan, Igor; Ryan, Kathy; Sarzynski, Mark A.; Scott, Laura J.; Scott, Robert A.; Sidney, Stephen; Siggeirsdottir, Kristin; Smith, Albert V.; Smith, Jennifer A.; Sonestedt, Emily; Strøm, Marin; Tai, E. Shyong; Teo, Koon K.; Thorand, Barbara; Tönjes, Anke; Tremblay, Angelo; Uitterlinden, Andre G.; Vangipurapu, Jagadish; van Schoor, Natasja; Völker, Uwe; Willemsen, Gonneke; Williams, Kayleen; Wong, Quenna; Xu, Huichun; Young, Kristin L.; Yuan, Jian Min; Zillikens, M. Carola; Zonderman, Alan B.; Ameur, Adam; Bandinelli, Stefania; Bis, Joshua C.; Boehnke, Michael; Bouchard, Claude; Chasman, Daniel I.; Smith, George Davey; de Geus, Eco J. C.; Deldicque, Louise; Dörr, Marcus; Evans, Michele K.; Ferrucci, Luigi; Fornage, Myriam; Fox, Caroline; Garland, Theodore; Gudnason, Vilmundur; Gyllensten, Ulf; Hansen, Torben; Hayward, Caroline; Horta, Bernardo L.; Hyppönen, Elina; Jarvelin, Marjo-Riitta; Johnson, W. Craig; Kardia, Sharon L. R.; Kiemeney, Lambertus A.; Laakso, Markku; Langenberg, Claudia; Lehtimäki, Terho; Marchand, Loic Le; Alizadeh, Behrooz Z.; Boezen, H. Marike; Franke, Lude; Swertz, Morris; Wijmenga, Tjitske Nienke; van der Harst, Pim; Navis, Gerjan; Rots, Marianne; Wolffenbuttel, Bruce H. R.; Magnusson, Patrik K. E.; Martin, Nicholas G.; Melbye, Mads; Metspalu, Andres; Meyre, David; North, Kari E.; Ohlsson, Claes; Oldehinkel, Albertine J.; Orho-Melander, Marju; Pare, Guillaume; Park, Taesung; Pedersen, Oluf; Penninx, Brenda W. J. H.; Pers, Tune H.; Polasek, Ozren; Prokopenko, Inga; Rotimi, Charles N.; Samani, Nilesh J.; Sim, Xueling; Snieder, Harold; Sørensen, Thorkild I. A.; Spector, Tim D.; Timpson, Nicholas J.; van Dam, Rob M.; van der Velde, Nathalie; van Duijn, Cornelia M.; Vollenweider, Peter; Völzke, Henry; Voortman, Trudy; Waeber, Gérard; Wareham, Nicholas J.; Weir, David R.; Wichmann, Heinz-Erich; Wilson, James F.; Hevener, Andrea L.; Krook, Anna; Zierath, Juleen R.; Thomis, Martine A. I.; Loos, Ruth J. F.; Hoed, Marcel den (Peer reviewed; Journal article, 2022)
      Although physical activity and sedentary behavior are moderately heritable, little is known about the mechanisms that influence these traits. Combining data for up to 703,901 individuals from 51 studies in a multi-ancestry ...
    • Pharmacologic and Genetic Downregulation of Proprotein Convertase Subtilisin/Kexin Type 9 and Survival from Sepsis 

      Lawler, Patrick R.; Manvelian, Garen; Coppi, Alida; Damask, Amy; Cantor, Michael N.; Ferreira, Manuel A. R.; Paulding, Charles; Banerjee, Nilanjana; Li, Dadong; Jorgensen, Susan; Attre, Richa; Carey, David J.; Krebs, Kristine; Milani, Lili; Hveem, Kristian; Damås, Jan Kristian; Solligård, Erik; Stender, Stefan; Tybjærg-Hansen, Anne; Nordestgaard, Børge G.; Hernandez-Beeftink, Tamara; Rogne, Tormod; Flores Perez, Carlos Antonio; Villar, Jesús; Walley, Keith R.; Liu, Vincent X.; Fohner, Alison E.; Lotta, Luca A.; Kyratsous, Christos A.; Sleeman, Mark W.; Scemama, Michel; Delgizzi, Richard; Pordy, Robert; Horowitz, Julie E.; Baras, Aris; Martin, Greg S.; Steg, Philippe Gabriel; Schwartz, Gregory G.; Szarek, Michael; Goodman, Shaun G. (Peer reviewed; Journal article, 2023)
      OBJECTIVES: Treatments that prevent sepsis complications are needed. Circulating lipid and protein assemblies—lipoproteins play critical roles in clearing pathogens from the bloodstream. We investigated whether early ...